Dead space guided recruitment allows avoiding regional overdistension or reduction in cardiac output in critical care patients with ALI or ARDS. Lung recruitment is a dynamic process that combines recruitment manoeuvres (RMs) with positive end expiratory pressure (PEEP) and low Vt to recruit collapsed alveoli. Different dead space indices can provide useful information in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) patients, where changes in microvasculature are the main determinants for the increase in dead space and consequently a worsening of the outcome. Dead space is not routinely measured in critical care practice, because the difficulties in in interpreting capnograms and the different methods of calculations. ![]() She received a 1st class Honours and the Thoracic Society of Australia and New Zealand Young Investigator Award at the annual scientific meeting in Tasmania.Dead space is the portion of each tidal volume that does not take part in gas exchange and represents a good global index of the efficiency of the lung function. This project was completed by Honours student Mei Ming Chan. The latter finding suggests inhaled bronchodilators are preferentially distributed to lung regions served by the more patent airways resulting in a greater degree of non-uniform ventilation. The effect of bronchodilators was to decrease the degree of non-uniform ventilation in the healthy group but to worsen it in our asthmatic subjects. In both subject groups we found the flow-dependence of dead space decreased at higher lung volumes. ![]() In this study we further investigated the effect of expired flow on the measurement of airway volume (flow-dependence of anatomical dead space) by investigating the effect of lung inflation and inhaled asthma therapy (bronchodilators) in healthy and asthmatic subjects.
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